Neural Plasticity is a new defined condition where there is uncontrolled pain or under-Treated Pain.
Unrelieved Pain -> Increase excessive nitric acid release -> block potassium channel -- decrease effects of opioids
Unrelieved Pain -> Increase excessive nitric acid release -> increased substance P-> Increase excitability of pain receptor -> increase transmission of pain signals from peripheral sites -> minor stimulus cause unexpected pain
Unrelieved pain -> increase c-fos protein ->increase sensitization of spinal cord -> brain ->uncontrolled pain
Prolonged activation of pain receptors -> cause neural cells to grow new connective endings -> pain spread from original organ -> pain become more diffuse and difficult to localize
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